Global prevalence and control of hypertension jama. Association of psychosocial risk factors with risk of acute myocardial infarction in 11 119 cases and 648 controls from 52 countries the interheart study. The overall prospective urban rural epidemiology pure study is a prospective, standardized collaborative study 7,8 in which we report a crosssectional analysis of baseline data to assess the prevalence, awareness, treatment, and control of hypertension by the economic status of countries and by sex, age group, location urban vs rural, and. Risk factors for ischaemic and intracerebral haemorrhagic. Physical activity levels, sport activities, and risk of. The interheart study showed the feasibility, value, and importance of a large standardised international casecontrol study 29 972 participants to establish the importance of, and relation between, key risk factors for myocardial infarction in 52 countries of high, middle, and low income, with participation from every inhabited. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. One in five of your patients could suffer a heart attack in the near futureunless you take steps to ensure their heart health. Evidencebased information on interheart study from hundreds of trustworthy sources for health and social care. Lipids, lipoproteins, and apolipoproteins as risk markers. Association of risk factors with acute myocardial infarction.
Click export csv or ris to download the entire page or use the checkboxes to select a subset of records to download. Many of the resulting clinical and public health policies in these highincome regions are being applied in lowerincome regions, but. Articles introduction worldwide, cardiovascular disease is estimated to be the leading cause of death and loss of disabilityadjusted life years. Sex differences in risk factors for myocardial infarction. The most important risk factor by far was cholesteroltwice as important as exercisefollowed by smoking. Patterns of alcohol consumption and myocardial infarction. Obesity and the risk of myocardial infarction in 27 000 participants from 52 countries. Yusuf s, hawken s, ounpuu s, dans t, avezum a, lanas f, mcqueen m, budaj a, pais p, varigos j, lisheng l. Stroke is the second leading cause of death and disability globally 1 yet is highly preventable. About half of the increase in risk associated with low education was due to modifiable lifestyle factors.
Results for interheart study 1 40 of 58 sorted by relevance date click export csv or ris to download the entire page or use the checkboxes to select a subset of records to download export csv export ris 10 per page 50 per page 100 per page 250 per page. Ancel keys and salim yusuf are both pioneers in preventive cardiology. Education and risk for acute myocardial infarction in 52. Obesity and the risk of myocardial infarction in 27 000. The odds ratios differ from 111 99% ci 0897 for central and eastern europe to 2.
Article in the lancet 3649438 january 2004 with 208 reads. Interheart a global study of risk factors for acute. Investigators note that the impact of the risk factors. Interheart risk modifiable factors in micardio infraction 2004. It is generally accepted that this association is explained by a combination of predominantly known risk factors and genetic variants 10. Estimating modifiable coronary heart disease risk in. Citations may include links to fulltext content from pubmed central and publisher web sites. We evaluated pa at work and leisure time in relation to acute myocardial infarction ami in chinese population. Svs was involved in the with risk of acute myocardial infarction in 11119 cases and 648 controls from 52 design and, along with sr and ckc, assisted in interpretation and writing the countries the interheart study.
Despite more than 80% of the global burden of cardiovascular diseases now occurring in low and middleincome countries,1 most of what we know about the causes of these diseases comes from studies of populations in north america and western europe. The results of the interheart study1 show that the factors associated with coronary heart disease are essentially the same wherever in the world people experience an acute myocardial infarction. Parental history and myocardial infarction risk across the. The incidence of cardiovascular disease is determined by a complex interaction of risk factors acting over the lifecourse. Lancet 2004 sep 11 most studies of modifiable risk factors for myocardial infarction have been conducted in developed countries. Abnormal lipids, smoking, hypertension, diabetes, abdominal obesity, psychosocial factors, consumption of fruits, vegetables, and alcohol, and regular physical activity account for most of the risk of myocardial infarction worldwide in both sexes and at all ages in all regions. The combination of the nine risk factors in the interheart study explain, among. The further import of interheart is that its data allow. The world health organization estimates that in 2010, coronary heart disease chd will be the leading cause of death globally, causing 30. The most downloaded articles from the lancet in the last 90 days. Who, dh, foresight, us task force on prevention of disease.
Our aim was to compare the apolipoproteins and cholesterol as indices for risk of acute myocardial infarction. Publications home of jama and the specialty journals of the. Download limit exceeded you have exceeded your daily download allowance. The interheart study was funded by the canadian institutes of health research, the heart and stroke foundation of ontario, and the international clinical epidemiology network. Yusuf, interheart investigatorsassociation of psychosocial risk factors with risk of acute myocardial infarction in 11119 cases and 648 controls from 52 countries the interheart study. In the study, 2909 patients with incident cases of acute myocardial infarction ami and 2947 control subjects free of heart disease from 27 regions in china were enrolled between february 1999 and march 2003. Jun 25, 2015 interheart risk modifiable factors in micardio infraction 2004 1. Publications home of jama and the specialty journals of. We congratulate salim yusuf and colleagues sept 11, p 9371 on their carefully done study of risk factors for myocardial infarction in 52 populations worldwide. The lancet vol 364, issue 9438, pages 9091010 1117. Pdf hosted at the radboud repository of the radboud. Volume 364, issue 9438, 1117 september 2004, pages 937952. These lessons from interheart and other studies are now being applied in the pure prospective urban rural epidemiology study in 25 low, middle, and highincome countries around the world, with 170 000 participants target of 200 000 currently enrolled.
Pdf effect of potentially modifiable risk factors associated with. Demographics and prevalence of risk factors in cases and controls in the interheart study. There is an enormous amount of literature on psychological stress and cardiovascular disease. Pubmed comprises more than 26 million citations for biomedical literature from medline, life science journals, and online books. Risk factors for myocardial infarction in women and men. Liu lisheng, on behalf of the interheart study investigators september 3, 2004. Interheart study, undertaken in a large number of patients. Interheart investigators, association of psychosocial risk factors with risk of acute myocardial infarction in 11119 cases and 648 controls from 52 countries the interheart study. A south african study supports evidence showing that stress, depression and other psychosocial factors can increase the risk of developing cardiovascular disease. Education and risk for acute myocardial infarction in 52 high.
Pdf education and risk for acute myocardial infarction. Volume 364, issue 9438 pages 9091010 1117 september 2004. Values shown are the hr 95% ci for major vascular events n 36 184 by quintiles of total physical activity after adjustment for age, sex, region, household income, education, alcohol consumption, smoking, fresh fruit intake, sedentary leisure time, and selfreported general health status. Citescore measures the average citations received per document published in this title. This issue can be addressed through primary and secondary prevention.
Psychiatric patients have more modifiable risk factors for coronary artery disease cad compared with the general population. Physical activity and anger or emotional upset as triggers. Impact of a genetic risk score on myocardial infarction. The interheart study was a global casecontrol study including participants from 52 countries in which nine modifiable risk factors were found to explain greater than 90% of acute mi in young and older individuals, women and men, across all major ethnic groups. Unveiling the causes of heart disease in china heart. Citescore values are based on citation counts in a given year e. Ysusuf and others published interheart study find, read and cite all the research you need on researchgate. Each overcame significant obstacles to demonstrate, through large international studies, how culture and environment influence cardiovascular disease. Article in the lancet september 2004 impact factor. Published in 2004, the effect of potentially modifiable risk factors associated with myocardial infarction interheart casecontrol study enrolled 15,152 cases and 14,820 age and sex matched controls worldwide across all six habitable continents.
Risk factors for acute myocardial infarction in latin america the. Effect of potentially modifiable risk factors associated. Vol 364 september 11, 2004 937 effect of potentially modi. Updated with slides results of the interheart study have shown that nine modifiable risk factors predict more than 90% of acute mi cases. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries the interheart study. The interheart study done in 52 countries, emphasizes the role of behavioral and. Full text is available as a scanned copy of the original print version. The main results of the interheart study were reported at the. Low education was the socioeconomic status marker most consistently associated with increased risk for acute myocardial infarction in this study which comprised 52 countries. Aug 14, 2010 rosengren a, hawken s, ounpuu s et al 2004 association of psychosocial risk factors with risk of acute myocardial infarction in 11119 cases and 648 controls from 52 countries the interheart study. Risk factors for acute myocardial infarction in latin. Statin use and cardiovascular risk factors in diabetic. Yusuf s1, hawken s, ounpuu s, dans t, avezum a, lanas f, mcqueen m, budaj a, pais p, varigos j, lisheng l.
We congratulate annika rosengren and colleagues sept 11, p 9531 on their well done study. What about the interheart study on heart attack risk factors. We agree that the nine risk factors they studied account for most, if not all, of the populationattributable risk of myocardial infarction. Association of risk factors with acute myocardial infarction in middle eastern countries. Potentially modifiable risk factors associated with. Our new crystalgraphics chart and diagram slides for powerpoint is a collection of over impressively designed datadriven chart and editable diagram s guaranteed to impress any audience. Physical activity levels, sport activities, and risk of acute myocardial infarction. Mobile technology for primary stroke prevention stroke. Dietary patterns and the risk of acute myocardial infarction. Download the understanding the publishing process pdf. Physical activity pa during leisure time has been inversely associated with cardiovascular disease risk in the western populations. Pdf education and risk for acute myocardial infarction in. Results for interheart study 1 10 of 59 sorted by relevance date click export csv or ris to download the entire page or use the checkboxes to select a subset of records to download export csv export ris 10 per page 50 per page 100 per page 250 per page. Effect of potentially modifiable risk factors associated with ami in 52 countries the interheart study.
Chart and diagram slides for powerpoint beautifully designed chart and diagram s for powerpoint with visually stunning graphics and animation effects. However, we think that the need to rely on a selfreported history of hypertension could well. Whether lipoproteins are better markers than lipids and lipoproteins for coronary heart disease is widely debated. Physical activity levels, sport activities, and risk of acute. This finding suggests that approaches to prevention can be based on similar principles worldwide and have the. Effects of potentially modifiable risk factors associated with myocardial infarction in 52 countries the interheart study. Results of the interheart study in china show all authors xiaoru cheng, md 1. May 27, 2016 in a crosssectional multicenter study of consecutive patients without previous ascvd hospitalized with a first mi in 20102012, we obtained information on diabetic status, statin use, and cardiovascular risk factors prior to mi. The study population consisted of 1622 patients with first mi 63 % men, 228 of whom had known diabetes before mi. Physical activity and risk of major cardiovascular diseases.
Rosengren a, hawken s, ounpuu s, sliwa k, zubaid m, almahmeed wa, blackett kn, sitthiamorn c, sato h, yusuf s. For this study to inadvertently divert attention from this additional avoidable factor. In response to kalina kaweckajaszcz and piotr jankowskis question as to why psychosocial factors seem to have little effect in central and eastern europe in the interheart study, there are two possible explanationsa real heterogeneity versus a methodological artifact, due to loss of meaning during translation of questionnaires, or simply the play of chance. The interheart study is uniquely positioned to address the. Objectives to investigate sex differences in risk factors for incident myocardial infarction mi and whether they vary with age. Effect of potentially modifiable risk factors associated with.
This paper will explore the origins and outcomes of their landmark studies. The designated discussant at the european society of cardiology congress, where the results were first reported, lamented mankind is doing a. What about the interheart study on heart attack risk. Main outcome measure incident fatal and nonfatal mi. Erectile dysfunction and subsequent cardiovascular disease. Cardiovascular disease is multifactorial in origin, and a number of potentially modifiable risk factors interplay to create the phenotype susceptible. Risk factors for early myocardial infarction in south asians. As previously described, the interheart study was a casecontrol study of first ami completed in 262 centers across 52 countries. Association of psychosocial risk factors with risk of acute myocardial infarction in 11119 cases and 648 controls from 52 countries the interheart study. Physical activity and anger or emotional upset as triggers of. Get a printable copy pdf file of the complete article 350k.
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